Gastric Emptying Projects

Briefly:  Gastric emptying, usually by radionuclides, has been the standard for diagnosis of disordered gastric function. Our projects have paralleled the evolution of gastric emptying testing.

 History:  Radionuclides began to be used for the quantification of gastric emptying in the 1980s. However the testing was not standardized. In addition, gastric emptying’s correlation with other measures of physiologic function were no clear.

Projects:  From the 1980’s on,  projects have tried to use emptying of both solids and liquid, wherever possible. The main focus has been to document gastric emptying at baseline and in response to interventions. Another focus has been to explore the interaction of nutritional, autonomic and enteric measures with gastric emptying.

 Original Publications, chronologically:

Abell TL, Malagelada JRM, Lucas AL, Brown MC, Camilleri M, Go VL, Azpiroz F, Callaway CW,  Kao PC, Zinsmeister AL, Huse D. Gastric electromechanical and neurohormonal function in anorexia nervosa. Gastroenterology. 1987: 93:958-965.

Abell TL, Kim CH, Malagelada JR.  Idiopathic cyclic nausea and vomiting – a disorder of gastrointestinal motility?  Mayo Clin Proc. 1988: 63; 1169-1175.

Camilleri M, Malagelada JR, Abell TL, Brown ML, Hench V, Zinsmeister AR: Effect of six weeks of treatment with cisapride in gastroparesis and intestinal pseudoobstruction.  Gastroenterology 1989: 96; 704-712.

Abell TL, Camilleri M, Hench VS, Malagelada JR.  Gastric electromechanical function and gastric emptying in diabetic gastroparesis.  Eur J Gastroenterol Hepatol. 1991: 3; 163-167.

Gaber AO, Oxley D, Karas J, Cardoso S, Hathaway, Shokouh-Amiri MH, Jensen SL, Abell TL. Changes in gastric emptying in recipients of successful combined pancreas-kidney transplants. Dig Dis.  1991: 9; 437-443.

Hathaway DK, Abell TL, Cardoso S, Hartwig D, Elmer D, Horton J, Lawrence l, Gaber L, Gaber AO. Improvement in autonomic function following pancreas-kidney versus kidney-alone transplantation. Transplantation Proceedings. 1993: 25; 1306-1308, 1993.

Hathaway DK, Abell TL, Cardoso S, Hartwig MS, Gebely SE, Gaber AO: Improvement in autonomic and gastric function following pancreas-kidney versus kidney-alone transplantation and the correlation with quality of life. Transplantation 1994: 57; 816-822.

Abell TL, Cardoso S, Schwartzbaum J, Familoni B, Wilson R, Massie D: Diabetic gastroparesis is associated with an abnormality in sympathetic innervation.  Eur J Gastroenterol Hepatol. 1994: 6; 241-247.

Gaber OA, Hathaway DK, Abell TL, Cardoso S, Hartwig MS, Gebely SE. Improved Autonomic and Gastric Function in Pancreas-Kidney vs. Kidney-Alone Transplantation Contributes to Quality of Life. Transplantation Proceedings. 1994: 26; 515-516.

Tougas G, Eaker EY, Abell TL, Abrahamsson H, Boivin M, Chen J, Hocking MP, Quigley EM, Koch KL, Tokayer AZ, Stanghellini V, Chen Y, Hizinga JD, RydenJ, Bourgeois I, McCallum RW. Assessment of gastric emptying using a low fat meal: Establishment of international control values. Am J Gastroenterol. 2000: 95; 1456-1462.

Abell TL, Van Cutsem E, Abrahamsson H, Huizinga JD, Konturek JW, et al. Gastric electrical stimulation in intractable symptomatic gastroparesis. Digestion. 2002: 66; 204-212.

Abell TL, McCallum R, Hocking M, Koch K, Abrahamsson H, et al. Gastric       electrical stimulation for medically refractory gastroparesis. Gastroenterolology. 2003: 125; 421-428.

Curuchi Anand, Amar Al-Juburi, Babajide Familoni, Hani Rashed, Teresa Cutts, Nighat Abidi, William Johnson, Anil Minocha, Thomas L. Abell.Gastric Electrical Stimulation is Safe and Effective: A Long-Term Study for Patients with Drug Refractory Gastroparesis in Three Regional Centers. Digestion. 75 (2-3):83-89, May 18 2007.

Salameh JR, Aru GM, Bolton W, Abell TL. Electrostimulation for intractable delayed             emptying of intrathoracic stomach after esophagectomy. Ann Thorac Surg. 2008;     85(4): 1417-9.   With invited commentary:  Rubin J; Ann Thorac Surg. 2008;85(4); 1420.

C Christensen, WD Johnson, TL Abell.  Cyclic Vomiting Pattern: GET and EGGs are more abnormal in DM GP patients with migraine than without, Scan Journal of GI, 2008, Vol. 43, No. 9, Pages 1076-1081

Kedar A, Nikitina Y, Abell KB, Vedanarayanan V, Griswold ME, Subramony C, Abell TL:  Gastric dysmotility and low serum vitamin D levels in patients with gastroparesis.  Horm Metab Res. 2013 Jan;45(1):47-53. doi: 10.1055/s-0032-1323689. Epub 2012 Sep 6.

Aurora SK, Papapetropoulos S, Kori SH, Kedar A, Abell TL:  Gastric stasis in migraineurs: Etiology, characteristics, and clinical and therapeutic implications.  Cephalalgia. 2013 Apr;33(6):408-15

Abstracts (numerous—available on request)

Final comments: Recent work has focus on re-analysis of normal control data for gastric emptying and it’s correlation with other measures of gastric function.

[updated 12 June 2014 by TLAbell]

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